Protein, Cortisol, and GABA: Why Moderating Protein Reduces Anxiety (and Lengthens Life)

Protein, composed of amino acids, is the building block molecule. For this reason, we usually think of it as constructing our bones, our skin, and our muscles. A lesser-known fact of amino acids, however, is that they are also the building blocks of neurotransmitters. This means that when certain amino acids break down from proteins … Read more

The GABA Neurotransmitter: Another Link Between Diet, Hormones, Mental Health, and Sleep

Neurotransmitters: Exciting and Inhibiting Gamma-Amino-Butyric-Acid, or GABA, is the chief inhibitory neurotransmitter in the human brain. Along with serotonin, dopamine, glutamate, glycine, histamine, and norepinephrine, among dozens of other neurotransmitters, GABA regulates brain function. Different neurotransmitters are in relationship with different types of receptors, and these receptors signal excitation or inhibition. For this reason, neurotransmitters … Read more

Paleo and PCOS

A lot of women who have PCOS try the paleo diet to help them overcome the PCOS. The majority of them see great, quick results. Paleo helps them achieve greater weight loss, improve their insulin sensitivity, and regain their fertility. Paleo also reduces inflammation, enhances the nutrient content of the diet, and helps balance hormones. … Read more

Neuropeptide Y: Appetite, Macronutrients, and Yo-Yo Dieting, or, Why Restriction Breeds Carb-Addicts and Disordered Eaters

Neuropeptide Y is one of several neuromodulators involved in regulating feeding. These include classic neurotransmitters such as serotonin, GABA, or dopamine, molecules derived from fatty acids like endocannabinoids, and neuropeptides. (All of which I will discuss at length eventually.) Every neuromodulator can be classified as orexic or anorexic. Orexic cells drive feeding. Anorexic cells do … Read more

Hypocretin Neurons: The Link Between Fasting, Stress, and Arousal, or, Why Fasting Breeds Insomniacs

There is a hell of a dichotomy occurring in the Paleo blogosphere this month. 99 percent of the time I am pleased as Pooh stuck up a honey tree, nestled in my esoteric corner of paleo-feminist rage, but every once in a while I wish more people could hear what I have to say. Today … Read more

Leptin, Sleep, and Obesity: Is Reduced Sleep Making America Fat?

The literature on sleep and obesity is becoming dense. Lots of things happen to people when they sleep. One of them has to do with appetite regulation, so many researchers are coming to believe that sleep plays a dominant role in today’s vast American Overfeed. This hunch is supported by striking correlations. In 1960, a … Read more

The HPA axis: Psychological Stress and Hypothalamic Amenorrhea

I’m going to pick up here where I left off on my last post. There, I covered the role that exercise and energy deficits play in HPA-axis-induced amenorrhea. Here, I cover the effects of psychosocial stress, and also how the two kinds of stress play off of each other. Hypothalamic amenorrhea (HA) typically results from … Read more